New research reveals patients with end-stage ankle arthritis can expect enhanced quality of life within six months of surgical reconstruction.
Engineers have developed neutrophil ‘nanosponges’ that can safely absorb and neutralize a variety of proteins that play a role in the progression of rheumatoid arthritis. Injections of these nanosponges effectively treated severe rheumatoid arthritis in two mouse models. Administering the nanosponges early on also prevented the disease from developing. The nanosponges are nanoparticles of biodegradable polymer coated with the cell membranes of neutrophils, a type of white blood cell.
An international research group has completed testing a new drug to treat rheumatoid arthritis. The drug is effective in patients with moderate to severe forms of the disease who have shown an inadequate response to conventional disease modifying drugs.
An unexpected discovery in two disease-linked proteins could shed light on human immune system disorders, including a rare and often fatal childhood disease called hemophagocytic lymphohistiocytosis (HLH).
Researchers have found that carbohydrate composition of diets increased the risk of osteoarthritis in laboratory mice — even when the animals didn’t differ in weight.
Immunologists have demonstrated that ILC2, a group of rare lymphoid cells, play a key role in the development of inflammatory arthritis. ILCs have several functional similarities to T-cells and are important agents of our congenital immune system. The researchers’ findings could form the basis for new approaches for treating rheumatoid arthritis.
The finding could lead to targeted therapies for chronic conditions.
Researchers have identified a new gene that plays a critical role in regulating the body’s immune response to infection and disease.
Overweight and obese individuals with knee osteoarthritis can reduce pain and significantly improve function and mobility with weight loss. New research reveals that a 20% or more weight loss has the added benefit of continued improvement in physical health-related quality of life along with an additional 25% reduction in pain and improvement in function.
An algorithm to monitor the joints of patients with arthritis, which could change the way that the severity of the condition is assessed, has been developed by a team of engineers, physicians and radiologists.