Rheumatoid arthritis meets precision medicine

Scientists are bringing precision medicine to rheumatoid arthritis for the first time by using genetic profiling of joint tissue to see which drugs will work for which patients, reports a new multi-site study. In the near future, patients won’t have to waste time and be disappointed with months of ineffective therapy, scientists said. Currently $2.5 billion a year is wasted on therapy that doesn’t work.

Causing inflammation to run out of fuel

Inflammation needs energy: An important source for this energy is oxygen, which is indispensable for the cells of the immune system to work properly. On the one hand, oxygen is an essential element required for cells to survive; on the other hand, it also adds fuel to the fire of inflammation. Researchers have discovered that the body skilfully uses this process to extinguish inflammation.