Autoimmune diseases such as psoriasis, lupus and rheumatoid arthritis more than double the risk of cardiovascular disease. A new study shows that immune cells that arise during autoimmune disease cause cholesterol to become trapped inside blood vessels.
An international research team has identified a genetic connection between rheumatoid arthritis-associated interstitial lung disease and idiopathic pulmonary fibrosis.
Researchers have developed a novel therapeutic treatment that has the potential to stop knee and spine osteoarthritis in its tracks.
New research reveals patients with end-stage ankle arthritis can expect enhanced quality of life within six months of surgical reconstruction.
Engineers have developed neutrophil ‘nanosponges’ that can safely absorb and neutralize a variety of proteins that play a role in the progression of rheumatoid arthritis. Injections of these nanosponges effectively treated severe rheumatoid arthritis in two mouse models. Administering the nanosponges early on also prevented the disease from developing. The nanosponges are nanoparticles of biodegradable polymer coated with the cell membranes of neutrophils, a type of white blood cell.
An international research group has completed testing a new drug to treat rheumatoid arthritis. The drug is effective in patients with moderate to severe forms of the disease who have shown an inadequate response to conventional disease modifying drugs.
An unexpected discovery in two disease-linked proteins could shed light on human immune system disorders, including a rare and often fatal childhood disease called hemophagocytic lymphohistiocytosis (HLH).
Researchers have found that carbohydrate composition of diets increased the risk of osteoarthritis in laboratory mice — even when the animals didn’t differ in weight.
Immunologists have demonstrated that ILC2, a group of rare lymphoid cells, play a key role in the development of inflammatory arthritis. ILCs have several functional similarities to T-cells and are important agents of our congenital immune system. The researchers’ findings could form the basis for new approaches for treating rheumatoid arthritis.
The finding could lead to targeted therapies for chronic conditions.